Another chromosomal assignment for a simian virus 40 integration site in human cells.

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Another chromosomal assignment for a simian virus 40 integration site in human cells.

Somatic cell hybrids derived from fusion of GM637, a human cell line transformed by simian virus 40, and mouse B82 cells were examined for simian virus 40 T antigen, V antigen, and viral DNA. All hybrid cell lines that contained viral DNA were T-antigen positive. Cells that did not have viral DNA were T-antigen negative. We determined that there is a single viral insertion in these hybrid cells...

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Simian virus 40 integration site in an adenovirus 7-simian virus 40 hybrid DNA molecule.

The E46(+) strain of Adenovirus 7 is a mixed-virus population containing defective Adenoviurs 7-SV40 hybrid particles and helper, nonhybrid Adenovirus 7 particles. We have applied electron microscopic mapping techniques to obtain a physical map of the genome of the hybrid particles present in E46(+)PL1, a substrain of E46(+) derived from a single two-hit plaque. DNA molecules extracted from pur...

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Stimulation of non-histone chromosomal protein synthesis in simian virus 40-infected simian cells.

The pattern of synthesis of non-histone chromosomal proteins in simian virus (SV) 40-infected African green monkey kidney cells was analyzed by polyacryl-amide gel electrophoresis to see whether the changes in chromosomal protein metabolism are involved in the viral-induced synthesis of cellular DNA and mRNA. During the prereplicative phase of infection, the rate of histone synthesis was decrea...

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Recombination in Simian Virus 40-infected Cells

The complete nucleotide sequence has been determined for three newly cloned evolutionary variants from two different independently generated evolutionary series ( 1 100 and 2100 series) of simian virus 4 0 (SV40). These naturally arising variants, designated ev-1110, ev-2102, and eu-2114, were isolated after five high multiplicity serial passages. The structure of the variants consists of a mon...

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Recombination in Simian Virus 40-infected Cells

The complete nucleotide sequence has been determined for three newly cloned evolutionary variants from two different independently generated evolutionary series ( 1 100 and 2100 series) of simian virus 4 0 (SV40). These naturally arising variants, designated ev-1110, ev-2102, and eu-2114, were isolated after five high multiplicity serial passages. The structure of the variants consists of a mon...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1978

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.75.9.4460